ABSTRACT. The present study aimed to evaluate the in vitro antimicrobial activity of pharmacologically important Adhatoda vasica plant extracts. Plant Adhatoda vasica L. Nees (Acanthaceae) commonly known as Malabar nut is an evergreen two – three m tall shrub, sometime used as. Adhatoda vasica (L.) (Acanthaceae) is used in the indigenous system of medicine in India. The alkaloid Vasicine was isolated from ethanolic extract of the .
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Clinical and Laboratory Standards Institute; Negative control was prepared using respective solvents. Sample ethanol extract Vasicine acetate showed minimum inhibitory concentration values against bacteria: Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals.
Antibacterial activity of adhatoda vasica leaf extract
DPPH 2,2-diphenylpicrylhydrazyl radical scavenging activity of Vasicine acetate was determined based on the method of Wang et al. It was studied for ahatoda, antioxidant, and anticancer activities. Al-Dhabi1 C. Introduction Natural products still remain the most important source for discovery of new and potential drug molecules.
The column was eluted with chloroform and chloroform: The plant is reported to show abortifacient [ 7 ], antimicrobial [ 89 ], and antitussive activities [ 10 ].
Cytotoxic effect of Vasicine acetate against A lung adenocarcinoma cancer cell line. Publications and Information Directorate; Journal of Natural Product and Vasicw Resources. The free radical scavenging activity was calculated as follows: Effect of Adhatoda vasica massage in pyorrhoea.
The MIC for bacteria was determined as the lowest concentration of o compound inhibiting the visual growth of the test cultures on the agar plate. Vasicine acetate showed moderate antibacterial activity compared to Vasicine. Vasicine acetate was obtained by acetylation of Vasicine recovered from A.
The worldwide threat of antimicrobial resistance. Structure of the compounds: UV-Visible spectra were taken in methanol on Thermo Fisher instrument.
Handbook adhaatoda Ayurvedic Medicinal Plants. The spot turned orange red on spraying with Dragendorff’s reagent. The radical scavenging activity of Vasicine acetate at different concentrations is shown in Table 3. Cytotoxic studies against A lung adenocarcinoma cancer cell line showed Vasicine acetate to be the most potent compound Table 4. BoxRiyadhSaudi Arabia.
Nees Acanthaceaeknown commonly as Malabar nut tree, is a shrub growing throughout the Indian peninsula. Vasicine is reported to have bronchodilatory, respiratory stimulant, and uterine stimulant effects [ 14 ].
Table 2 Minimum inhibitory concentration activith Vasicine acetate against tested bacteria and fungi. Separation was carried out at room temperature. The compound showed prominent cytotoxic activity in vitro against A lung adenocarcinoma cancer cell line.
Balachandran2 S. Sankar2 and K. Ignacimuthu123 C. The plant was identified by Dr. Antibacterial and antifungal activities were carried out using disc diffusion avhatoda [ 16 ]. Evaluation of actlvity activity of isoferulic acid in vitro. Estimates of worldwide burden of cancer in Cytotoxicity of each sample was expressed as IC 50 value. Conclusion Vasicine acetate was obtained by acetylation of Vasicine recovered from A.
Asian Journal of Microbiology, Biotechnology & Environmental Sciences Paper
Table 4 Cytotoxic adhqtoda of Vasicine acetate against A lung adenocarcinoma cancer cell line.
Journal of Obstetrics and Gynaecology of India. A voucher specimen No.